🏢 Pulp and Paper Building, Room 301
🔬 Research interest: protein and nucleic acid dynamics, allostery, enzyme catalysis, drug design, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry, differential scanning calorimetry
Research in the Mittermaier lab is focused on understanding protein and nucleic acid function at the atomic level. Researchers combine site-specific information on macromolecular motions gained from high-field solution state NMR spectroscopy with detailed thermodynamic information yielded by calorimetry and other biophysical techniques. This combined approach elucidates the mechanisms underlying a variety of fundamental biological phenomena including folding, catalysis and allostery, with applications to drug design, protein and nucleic acid engineering, and biologics development.