Youla S. Tsantrizos
🏢 Otto Maass Chemistry Building, Room 300
🔬 Research interest: structure-based design, synthesis of molecular tools to probe the function of biological targets
Dr. Tsantrizos’ program centers on the design and synthesis of molecular tools that can be used to probe biochemical pathways implicated in human diseases. The lab is currently investigating four biological targets: the human 1. farnesyl pyrophosphate synthase (hFPPS), 2. geranylgeranyl pyrophosphate synthase (hGGPPS), 3. metalloproteinase ZMPSTE24, and 4. the HIV-1 reverse transcriptase (RT). Under the large umbrella of each of these projects, the following three objectives summarize the main scope of research efforts: (a) implementation of structure-based screening methods that probe protein/ligand interactions; (b) development of synthetic methodologies amenable to enantioselective synthesis of structurally diverse heterocyclic and peptidomimetic ligands; (c) development of reliable structural and functional assays for guiding structure-activity relationship (SAR) studies. These studies are truly multidisciplinary, involving a seamless integration of synthetic organic chemistry, structural research and biochemistry.