Dr. Xia’s research focuses on computational biology and bioinformatics. The research goal is to construct genome-scale computer models of biomolecular networks with high spatial and temporal resolutions, and to use these genome-scale models to probe the design principles of biological networks and to study the systems biology of disease. Current research activities include: (1) computational structural biology, focusing on the prediction and analysis of protein structure and function, and the elucidation of evolutionary design principles of proteins; (2) computational systems biology, focusing on the prediction and analysis of protein networks, and the elucidation of evolutionary design principles of protein networks; (3) bioinformatics, focusing on the development and application of bioinformatics algorithms to analyze biological sequence, structural, and functional data.